Troubleshooting flickering issues

With the newest 1.05 update:

By switching to Very Light (other difficulties coming soon) and using Navigation Assistance and Enhanced Dodge with either Traversal Assistance, Text-to-Speech, Combat Audio Cues, or Traversal Audio Cues you gain temporary immunity each time Navigation Assistance or Enhanced Dodge is used. This immunity is removed when you fire a weapon.

 

Other things that may help:

• You can enable Slow Motion via Options → Accessibility → Combat Accessibility → Slow Motion → While Aiming or Toggle (depends on personal preference). This may assist in difficult combat encounters.
• You can also feel the boss lumbering towards you based on the vibration feedback from its footsteps. Big rumbles mean it is close. Run away to regroup.
• The boss is extremely lethal at close range. Navigation assistance (Options → Accessibility → Navigation and Traversal → Navigation Assistance) will direct you away from the boss; try to get some distance, land some shots, then keep moving.
• Using the flamethrower in short bursts and pipe bombs can cause the boss to stagger.
• Create distance by standing near a doorway if the rat king breaks through it takes some additional time allowing for one or two additional shots.
• Focus on the big enemy once it's down the other will scatter.
• If you are having trouble hearing certain cues go to Options → Audio → Volumes to turn down the Music and other volumes.